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Saat: Wendell Lim SYNTNETIC BIOLDGIST / UC San Francisco Arming the immune system to kill cancer-and more. hard to make T cells that kill only cancer with no collateral damage Hearing this, Lim 1996 frhod no atianh.kohe bonan realized the tools he d been tinkering with re ecould make CAR Txafer and more reliable Strge 2015. Lirnslab has been making aned i.cells One tequires a use mul WHEN WENDELL LIM BOoted up his blo SanErncisco in Phystathemisrylab.iugan rondso iDw URUBD Stem ns like ing SAat Harvard ouemnsteatsthrough 3arug genetic engineering Foryears he tinkered with yeast inserfing.code intoits DNA10 make it do thtngs never scen in nature Then. in 2010 he met a University of Penn sylvania oncologist named Carl June who was developing a cancer treatment called CAR T It involves genetically engineering T cells the assassins of the immune system tO create a clone army trained to find and desiroy a patient's unique cancer. In 2011 June published CAR Ts first breakthrough lode Others -Goo dre usinoiupp 0U88mo une moltcular markers to tdentlv cancer ke iwo-factor authenticatiot Firstgen CAR TIheraplesrely on a sigle lock and Key siwitch. Linm notes. but a tmorlk a com plex, mutating environment Thats why hes designing cells to read pattems of molecules. a bit like how facial recognition algorithms analyze faces He's also creating T cells that attack only when there's a critical mass of tumor specific molecules present, and a ver sion that Intercepts signals between tumor uccess, which set off a tsunani of clinical cells to stage assaults on the whole nerwork Lim expects some of his early T cell designs to be tested in humans within two years can also be deadly-it's But he's already looking beyond cancer, to hacking the whole immune system: Healing wounds, haltlng degeneration, preventing autommunity all of it could be guided by designer cells "The culture now is that CAR T is just a big toxin attached to an antibody Lim says. The idea that Immune cells are programmable computational devices that Can do many things iS pretty lar away, but I'm rials leading to (so Tar)two FDA approved reatments But june and ofhers were wor ried A clone army bopeful we changge that MEGAN MOLTENI White text and light background on glossy paper
Saat: Wendell Lim
 SYNTNETIC BIOLDGIST / UC San Francisco
 Arming the immune system to kill
 cancer-and more.
 hard to make T cells that kill only cancer
 with no collateral damage Hearing this, Lim
 1996 frhod no atianh.kohe bonan realized the tools he d been tinkering with
 re ecould make CAR Txafer and more reliable
 Strge 2015. Lirnslab has been making
 aned i.cells One tequires a
 use mul
 WHEN WENDELL LIM BOoted up his blo
 SanErncisco in
 Phystathemisrylab.iugan rondso iDw
 URUBD
 Stem
 ns like
 ing
 SAat Harvard ouemnsteatsthrough 3arug
 genetic engineering Foryears he tinkered
 with yeast inserfing.code intoits DNA10
 make it do thtngs never scen in nature
 Then. in 2010 he met a University of Penn
 sylvania oncologist named Carl June who
 was developing a cancer treatment called
 CAR T It involves genetically engineering T
 cells the assassins of the immune system
 tO create a clone army trained to find and
 desiroy a patient's unique cancer. In 2011
 June published CAR Ts first breakthrough
 lode Others
 -Goo dre
 usinoiupp
 0U88mo
 une moltcular markers to tdentlv cancer
 ke iwo-factor authenticatiot Firstgen
 CAR TIheraplesrely on a sigle lock and
 Key siwitch. Linm notes. but a tmorlk a com
 plex, mutating environment Thats why hes
 designing cells to read pattems of molecules.
 a bit like how facial recognition algorithms
 analyze faces He's also creating T cells that
 attack only when there's a critical mass of
 tumor specific molecules present, and a ver
 sion that Intercepts signals between tumor
 uccess, which set off a tsunani of clinical cells to stage assaults on the whole nerwork
 Lim expects some of his early T cell designs
 to be tested in humans within two years
 can also be deadly-it's But he's already looking beyond cancer, to
 hacking the whole immune system: Healing
 wounds, haltlng degeneration, preventing
 autommunity all of it could be guided by
 designer cells "The culture now is that CAR T
 is just a big toxin attached to an antibody
 Lim says. The idea that Immune cells are
 programmable computational devices that
 Can do many things iS pretty lar away, but I'm
 rials leading to (so Tar)two FDA approved
 reatments But june and ofhers were wor
 ried A clone army
 bopeful we changge that
 MEGAN MOLTENI
White text and light background on glossy paper

White text and light background on glossy paper

Saat: is pa en pu. ar vi satt P& en pub e nel blev vanner clag med bartendu Nar vi lag ignaset onskade Varand Zombie fide beaag Barhoppada på cn bat & rokteta iNar vi sa Maiden i Malmibme- Sades &ick ont fatterna Nar Vi gick vilse i London Skuhe haaa iHyde Park det Vay vi ondlon ko m hem barha NA Prdy franErike kramades kváll. Nis Varit en or och ort Slottstrid Mila deg mimo sas, o wilight Nar vi maluck Caula, Mir vit de sheriffen Vitraffadk Pa hin Disturbd Nac Annes ner dig frin Halvars cdn gea med HIMYH U&rfirsta de'y Sam Varade Ui Sa da gas.Nar phela natte oh spelade upf tkte Vi Sklle ki Cn mile snodd P&skn's. Nirdh kom till Malm sprans iniAi fimn.Ni ihch 9all h da kor 'a till mi nir Vi gich Pia födelco Nar vi hade AN Kuddar fi Somnade dir wti en ptog av arets kl berall D hem Pran Lin ar day gravi Nir Var the sto Spela Tueow nto kn dar Vi spenderade vintrar ele ra alt p& titanic ktentehn onen S A Pingis a yisna HATTRICK MOT: HINNERYD Adam iar ell 'sa DIG karlekstull bargo R Du haft bid att vafa med Om mårga raddningarMed dig, min kara n,jos Mftter en Stelpretur många Aina stunder en situation náchan rsta av. sliskaf med hialp avraven! Vioch de icrem bdels addat ett givet mal Pa VintramA Spelade vi land first&r viu varför allathade hockeys det tacklade r lvsterpusS n Suirmort heh's E stayed with ne arattis langa Oerhort viktigt atl vi bad Whan you avsluba med ett avgsn when my train was lak: hart!Det var aven p ur man du D riddain om Jenniealitid gladR tos ry kuar medd odin tills ar EN j behivde prata avI G3 Ojastanade s R5 d somnade nir True da Va markridd Saker s& stack vi till stan :Nir du alla dar bara vi seto& Tysanat pi american Nar vi skule Sitta pe hela tten osh a ag tyeker myeket tvállar nigra ol. Du lyssk ga rld om vara ll ut KiSsal baskarna Musik,s 4 n i att vi bida (n hade Saat Pifa nir den andra Sov Adnckise Autt lasa a Sova Pamorganana yarit istalle fir att Suart attglamma kello chabtroulktts don ken Saw Oerhart Skaj ihop!me rdven! hade sa fina San flyoure Such a & Sour vi varule med bten 8at fiske natur trevliet salls kapdancer Kapten.styman tre har hoft nar driddde ett mdl \ जरे Nor Vi Satt påen busshalphts A dam ad PirMin forsta'taf. metcorvesn alk & inget, och vi stulle oricka framfer allt mins:Suarsonvar den hra mi att al och hela km n te nar Soma .. bullar I'm turning 30 today, got an guitar from my wife. The text is memories with me from my friends! Going to take a while to read it all.
Saat: is pa en pu.
 ar vi satt
 P& en pub e nel
 blev vanner
 clag
 med bartendu
 Nar vi lag ignaset
 onskade Varand
 Zombie fide beaag
 Barhoppada på cn
 bat & rokteta
 iNar vi sa
 Maiden i Malmibme-
 Sades &ick ont
 fatterna Nar
 Vi gick vilse i
 London
 Skuhe haaa
 iHyde
 Park
 det
 Vay
 vi
 ondlon
 ko m hem
 barha
 NA
 Prdy
 franErike
 kramades
 kváll. Nis
 Varit
 en
 or och ort
 Slottstrid
 Mila deg
 mimo sas, o
 wilight
 Nar vi maluck
 Caula, Mir vit
 de sheriffen
 Vitraffadk Pa
 hin Disturbd
 Nac Annes
 ner dig frin
 Halvars cdn gea
 med HIMYH
 U&rfirsta de'y
 Sam Varade
 Ui Sa
 da gas.Nar
 phela natte
 oh spelade upf
 tkte
 Vi Sklle ki
 Cn mile snodd
 P&skn's. Nirdh
 kom till Malm
 sprans
 iniAi
 fimn.Ni
 ihch
 9all h da kor
 'a till mi
 nir
 Vi gich
 Pia födelco
 Nar vi hade
 AN Kuddar fi
 Somnade dir
 wti
 en
 ptog av arets kl
 berall
 D hem Pran Lin
 ar day
 gravi
 Nir
 Var
 the sto
 Spela
 Tueow
 nto kn dar
 Vi spenderade
 vintrar
 ele ra
 alt
 p& titanic
 ktentehn onen
 S
 A
 Pingis a yisna
 HATTRICK MOT:
 HINNERYD
 Adam iar ell 'sa
 DIG karlekstull
 bargo
 R
 Du
 haft bid att vafa med
 Om
 mårga raddningarMed dig, min kara
 n,jos
 Mftter en Stelpretur många Aina
 stunder
 en situation náchan rsta av.
 sliskaf
 med hialp avraven! Vioch de
 icrem bdels
 addat ett givet mal
 Pa VintramA
 Spelade vi land first&r viu varför allathade
 hockeys det tacklade r lvsterpusS n
 Suirmort
 heh's E stayed with ne
 arattis
 langa
 Oerhort viktigt atl vi bad Whan you
 avsluba med ett avgsn when my
 train was lak:
 hart!Det var aven p
 ur man du D riddain
 om Jenniealitid gladR
 tos
 ry
 kuar medd odin tills
 ar
 EN j behivde prata avI
 G3
 Ojastanade s
 R5 d somnade nir
 True
 da Va markridd
 Saker s& stack vi till stan
 :Nir du
 alla
 dar bara vi seto&
 Tysanat pi
 american
 Nar vi skule Sitta
 pe hela tten osh a
 ag tyeker myeket
 tvállar
 nigra ol. Du lyssk ga rld
 om vara
 ll ut
 KiSsal
 baskarna
 Musik,s
 4
 n i att vi bida (n hade
 Saat Pifa nir den andra Sov
 Adnckise
 Autt lasa a Sova Pamorganana
 yarit
 istalle fir att
 Suart attglamma
 kello
 chabtroulktts
 don ken
 Saw
 Oerhart Skaj ihop!me rdven!
 hade sa fina San flyoure Such a
 & Sour vi varule med bten 8at
 fiske natur trevliet salls kapdancer
 Kapten.styman tre har hoft nar driddde ett mdl
 \ जरे
 Nor Vi Satt påen busshalphts A dam ad PirMin forsta'taf.
 metcorvesn
 alk & inget, och vi stulle oricka framfer allt mins:Suarsonvar den
 hra mi
 att
 al
 och
 hela km n
 te nar
 Soma
 ..
 bullar
I'm turning 30 today, got an guitar from my wife. The text is memories with me from my friends! Going to take a while to read it all.

I'm turning 30 today, got an guitar from my wife. The text is memories with me from my friends! Going to take a while to read it all.